AB1367 EFFECTIVENESS OF REHABILITATION STRATEGIES IN PRIMARY FIBROMYALGIA SYNDROME: A SYSTEMATIC REVIEW AND META-ANALYSIS

Background Fibromyalgia is characterized by chronic inconsistent widespread pain and tenderness. It also associated with other comorbid symptoms like sleep disturbances, fatigue, cognitive impairments (memory mood disturbances), and/or irritable bowel syndrome. [1] Prevalence of fibromyalgia 2.7% globally, being slightly higher in middle aged women (4-9%). 75 to 100 % patients face depression, anxiety stress. The probability occurrence depression almost 40% at any stage the course fibromyalgia. [2] Patients usually report physical (e.g. appetite, sleep, sexual dysfunction) rather than mood-related psychological suicidal ideation, low self-esteem), however affective expression neuromarkers both cannot be isolate. [3] Reviews done till date are either oriented toward specific form exercise or towards outcome. We could not come across review which included all measurement multiple outcomes. Objectives aim this was 1) summarize evidence on effectiveness rehabilitation strategies syndrome (FMS) 2) determine most effective strategy for reducing people FMS. Methods PubMed, Ovid (Sp), Cochrane search engines were used identifying studies 1 July 2022. Randomized control trials (RCTs) that have passive group active primary secondary respectively. outcome measures Pain depression. Secondary one from fatigue healthy related quality life (HRQOL). Results A total 25 RCTs included. Separate random effect model meta-analysis performed randomised trial group. Mean difference Standard 95% confidence interval assess size. Studies showed moderate large positive effects (SMD -0.65, CI -0.93 -0.38; I2 = 72%) HRQOL(MD -5.40, -10.17 -0.62; 74%) but non-significant Furthermore, subgroup analysis short term protocol significant only, whereas long protocols HRQOL only time post-trial follow-up. represent non- results except mixed exercises (MD -4.78, -7.98 -1.57; 0%) HRQOL. Conclusion All HRQOL, has marginal efficacy maintained However, we differentiate best among those studies. References [1]Queiroz LP. Worldwide epidemiology topical collection Curr Headache Rep ; 17. Epub ahead print 2013. DOI: 10.1007/s11916-013-0356-5. [2]Kato K, Sullivan PF, Evengård B, et al. Importance genetic influences pain. Arthritis Rheum 2006; 54: 1682–1686. [3]Bair MJ, Robinson RL, Katon W, Depression Comorbidity: Literature Review. Arch Intern Med 2003; 163: 2433–2445. Acknowledgements: NIL. Disclosure Interests None Declared.